This study is a pilot clinical trial. The calculation of the sample size will be based on a drop-out rate of 20% in the clinical study, and 0.025% of the sample size will be taken as 90%, which is calculated to include 110 patients. The patient will randomly select any number from 001 to 110 from the sealed envelope and is assigned to the observation group (odd) and the control group (even) according to the parity of the number.
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