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Gene Set Enrichment Analysis

YL Yu Liu
SH Shirui Huang
MK Mengjiao Kuang
HW Huiyan Wang
QX Qipeng Xie
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To investigate the potential molecular mechanisms during LARGE1 alteration in lung cancer, the Spearman correlations analysis results of more than 20,000 genes with LARGE1 in lung adenocarcinoma in the TCGA database were downloaded via cBioPortal (cbiopartal.org).24,25 The genes were ranked by the Spearman’s rank r and subjected to Gene Set Enrichment Analysis (GSEA) via software, JAVA GSEA 3.0 (http://software.broadinstitute.org/gsea/index.jsp).26,27 The biologically defined gene sets “c2.cp.kegg.v7.1.symbols.gmt,” “c7.all.v7.1.symbols.gmt,” and “h.all.v7.1.symbols.gmt” were used as the reference databases.

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