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Descriptive statistics are expressed as median and interquartile ranges. The data were tested for normality using the Shapiro-Wilk test. The nonparametric Spearman’s rank correlation test was used to evaluate the dependence among the measured characteristics.
The nonparametric Mann-Whitney U test was used to evaluate differences between groups. Differences with a p-value less than 0.01 were selected as significant and data were acquired and analyzed using R v3.4.4 software environment [16].
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