4.15. Statistical analyses

The association between the SIGLEC1 null allele and the TB phenotypes was assessed by an enrichment analysis using a Chi‐squared test, a hypergeometric test, a proportion test or a logistic regression, according to the design of the cohorts. Mean or median changes were analyzed using a paired t‐test or a Mann–Whitney U‐test, respectively. Mean changes from 100% of data normalized to percentages were assessed with a one‐sample t‐test. Longitudinal values of bacterial replication were analyzed using linear models of mixed effects. Test results were considered significant at P < 0.05. All analyses and figures were generated with R or GraphPad Prism v.8 software.