Epilepsy- and autism-associated genes

We collected 977 genes, including gene clusters, associated with epilepsy from the expert-compiled list from Wang et al. (2017)¹⁰. These genes were manually curated and examined from multiple genetic databases and represent genes are directly related to epilepsy, or indirectly lead to epilepsy through influence on the central nervous system or other systems; the subgroups of epilepsy genes are defined in Table ​Table1.1. These 977 epilepsy-associated genes were mapped to 999 genes in the multiplex network. The number of genes increased because gene clusters were separated into individual genes. We also collected 913 autism-associated genes from the Simons Foundation Autism Research Initiative (SFARI) Gene (access date: January 5, 2020), a community-driven knowledgebase of autism spectrum disorder⁶⁰. SFARI Gene has the evidence and the strength of the genetic association for each gene; subgroups of autism genes are defined in Table ​Table1.1. These 913 autism-associated genes were also mapped to the multiplex network. In total there were 1707 epilepsy- and autism-associated genes.