The data were processed using SPSS version 18.0 statistical software. Measurement data were expressed as mean ± SEM. P < 0.05 was considered statistically significant. The experimental data were assessed by Student’s t test, one-way ANOVA, or two-way ANOVA procedure. Tukey’s post hoc tests were performed only if the F value in ANOVA achieved the necessary level of statistical significance. Equalization and randomization, were used for each group in both in vivo and in vitro experiments, including mouse allocation, experimental performance, data extraction, and data analysis.
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