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Co-inertia analysis

AD A. Das
EO E. O’Herlihy
FS F. Shanahan
PO P. W. O’Toole
IJ I. B. Jeffery
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Association between the fecal mycobiome and other datasets (bacteriome, metabolome and diet) from the same study population previously reported by Jeffery et al.13 was performed using co-inertia analyses.

For association analysis of each dataset, samples common to the mycobiome and the compared dataset was used. For shotgun species/genus data from 138 study participants (IBS: n = 80, control: n = 58) was transformed using Hellinger transformation. The dietary data based on the Food Frequency Questionnaire (FFQ) from 144 individuals (IBS: n = 80, control: n = 64) was used in the analysis where the frequencies were converted to per week consumption of food items. For the fecal metabolome, profiles from 142 participants (IBS: n = 80, Control: n = 62) were included and these were log10 transformed. The mycobiome profiles in all the comparisons was log10 transformed.

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