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Experimental model of tauopathy

JD Jing Di
IS Ibrar Siddique
ZL Zizheng Li
GM Ghattas Malki
SH Simon Hornung
SD Suman Dutta
IH Ian Hurst
EI Ella Ishaaya
AW Austin Wang
ST Sally Tu
AB Ani Boghos
IE Ida Ericsson
FK Frank-Gerrit Klärner
TS Thomas Schrader
GB Gal Bitan
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P301S-tau (Tg(Prnp-MAPT*P301S)PS19Vle) transgenic mice were obtained from Jackson laboratories and were bred and maintained by the UCLA Division of Laboratory Animal Medicine. Homozygous P301S-tau and wild-type littermates were used in this study. Mice were housed in groups of 5, under a 12-h light/12-h dark cycle at 21 °C, with food and water ad libitum. All the experiments were reviewed and carried out in accordance with National Research Council Guide for the Care and Use of Laboratory Animals, approved by the University of California-Los Angeles Institutional Animal Care Use Committee, and performed with strict adherence to the guidelines set out in the National Institutes of Health Guide for the Care and Use of Laboratory Animals.

Copyright and License information: The Author(s) ©2021
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