Kaplan-Meier and Receiver Operating Characteristic (ROC) Curve

Kaplan-Meier curves were performed to compare the RFS outcome between the high- and low-risk patients determined by the miRNA-based signature. The ROC curve was plotted with the R package “pROC”. The predictive value was assessed by the area under the ROC curve (AUC). In addition, nomogram ROC analysis was used to synthesize the miRNA-based signature with the clinicopathological features, as well as the laboratory test results. In addition, the Kaplan-Meier plot and log-rank analyses were used to determine the survival difference between high- and low-risk subgroups, and the univariate Cox analysis was used to generate the hazed ratio (HR) and 95% confidential interval (95% CI) among high- and low-risk subgroups.