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Intra-articular injection in mice
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One, two and four weeks after OA induction, intra-articular injections of EPZ-6438 or vehicle were performed through a trans-patellar tendon approach. Briefly, mice were anesthetized, and the area surrounding the right knee joint was disinfected with alcohol.A syringe with a 30G needle was inserted without any resistance in the capsule by passing under the patella. After injection, knees were massed to ensure even distribution of the solution.
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