2.3. General Procedure for Sulfonamide Synthesis

Primary amine (1.0 mmol) and KOH (powdered, 0.10 g, 1.8 mmol, 1.8 equiv.) were dissolved in dry CH₂Cl₂ (15.0 mL). A chosen sulfonyl chloride (1.0 mmol, 1.0 equiv.) was then introduced. The mixture was stirred for 24 h at room temperature. After addition of brine the mixture was extracted with dichloromethane. The organic phases were dried (Na₂SO₄), and evaporated to dryness after filtration through Celite^®. Thus obtained crude sulfonamides were purified using column chromatography on silica, and eluted with ethyl acetate/n-hexane (1:1 v/v).

The details of experimental procedures and the relevant physicochemical data of all newly prepared compounds together with copies of ¹H and ¹³C NMR spectra are gathered in Supplementary Materials.