ROP screening was performed for all very preterm infants (240/7–32) by qualified ophthalmologists with expertise, according to the Chinese guidelines for ROP screening [23]. Follow-up examinations were performed by the examining ophthalmologist based on retinal findings, classified according to the “International classification of retinopathy of prematurity revisited” [26, 27]. ROP was subdivided into stages 1–5 according to the classification and defined as follows [27]: (1) none: immature or mature vascularisation; (2) ROP: stage 1 or stage 2 ROP in zone II or III without plus disease; (3) type 1 ROP: zone I, any stage ROP with plus disease; zone I, stage 3 ROP without plus disease; zone II, stage 2 or 3 ROP with plus disease; (4) type 2 ROP: zone I, stage 1 or 2 ROP without plus disease or zone II, stage 3 ROP without plus disease; and (5) ROP requiring treatment was defined as type 1 ROP or worse. Termination of ROP screening was performed before 45 weeks postmenstrual age (PMA) [26].
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