Follow-up time was defined from the day of SRS until last clinical evaluation or MRI scan. Follow-up was performed at least every 3 months by contrast-enhanced MRI scans and clinical evaluation. For response evaluation, we decided to define local tumor progression through interdisciplinary decision of dermatologists, neuroradiologists and radiation oncologists, whenever the clinical diagnoses seemed reliable. Nevertheless, in some cases there were still doubts about the differentiation between CRN or local tumor progression. In the present study, these uncertain cases were evaluated separately as described in the following paragraph.
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