Assessment of cotton pellet-induced rat granuloma

The sterile cotton pellets were implanted by a single needle incision into both axillae regions of rats under ether anesthesia. Rats were randomly divided into five groups (n=10) once daily for 7 days for taraxasterol groups (2.5, 5 and 10 mg/kg, orally), control group (0.5% CMC-Na, orally), positive group (2.5 mg/kg DXM, intraperitoneally). On day 8, the wet cotton pellets were carefully dissected, weighed and dried at 60°C for 12 h. The granuloma formation was measured by the increase in dry weight of the pellets (Cai et al., 2014).