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BH Briana D. Hamamoto-Hardman
ES Eugene P. Steffey
DM Daniel S. McKemie
PK Philip H. Kass
HK Heather K. Knych
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For comparability of treatments, thermal nociceptive thresholds were standardized to thermal exclusion (%TE) as described previously [32], using the formula:

Where TT represents the thermal threshold, T0 the skin temperature and TC the thermal nociceptive cut-off temperature.

Statistical analyses using commercially available software (Stata/IC 15.1, StataCorp LP, TX, USA) were used to determine significant differences in pharmacokinetic and pharmacodynamic parameters. For pharmacokinetic analysis, differences in parameters between dose groups were assessed and for pharmacodynamic data, differences between baseline and each time point and between dose groups were evaluated. Data were analyzed using a mixed effects analysis of variance, with the horse as the random effect and time and dose as the fixed effects. Post-hoc comparisons were performed with a Bonferroni multiple comparison adjustment to preserve a nominal significance level of 0.05.

Copyright and License information: The Author(s) ©2020
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