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Monoclonal antibodies.

MT Marina Tuyishime
CG Carolina Garrido
SJ Shalini Jha
MM Matt Moeser
DM Dieter Mielke
CL Celia LaBranche
DM David Montefiori
BH Barton F. Haynes
SJ Sarah Joseph
DM David M. Margolis
GF Guido Ferrari
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Six human mAbs targeting different regions of the Env, the non-neutralizing C1C2 (A32) (38), CD4bs (CH557) (39), V2 glycan (PG9) (40), V3 glycan (PGT121) (41), gp120-gp41 interface (PGT151) (42), and MPER (DH511.2K3) (43), were isolated from HIV-1–infected individuals, expressed as IgG1, and optimized for Fcγ receptor binding on the effector cells (80).

Copyright and License information:  ©2020 American Society for Clinical Investigation

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