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Calculation of tumor doubling time and tumor inhibition rate

XZ Xiangyu Zhang
JC Jia Chen
CC Cheng Cheng
PL Ping Li
FC Fangfang Cai
HX Huangru Xu
YL Yanyan Lu
NC Nini Cao
JL Jia Liu
JW Jigang Wang
ZH Zi-Chun Hua
HZ Hongqin Zhuang
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For calculating tumor doubling time (TDT), the equation of Schwartz25 was used:

Where t is the total number of treatment days, D0 is the diameter at the start of treatment, Dt is the diameter after time t, and the diameter is expressed as 1/2 × (length + width).

For calculating tumor growth inhibition value (TGI), the formula (2) was used:

Where t is the total number of treatment days, Wt is the tumor weight of the treatment group after time t, Wt0 is the tumor weight of the control group after time t, and n is the number of mice in the control group.

All data statistics were performed using GraphPad Prism v8.0.

Copyright and License information: The Author(s), ©2020
This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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