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The IBU release profile was tested in the Hanson Research SR8PLUS dissolution station combined with Dissoette II Autosampler and spectrophotometer UV/vis Jasco V530 for binary mixtures of IBU with the large content of acMAL (IBU+83 wt % acMAL, IBU+86 wt % acMAL, and IBU+87.5 wt % acMAL). The studies were performed in Ph.Eur. app.2 at 50 rpm. The tested samples containing 50 mg of IB were poured into vessels filled with 900 mL of purified water preheated up to 37 ± 0.5 °C. The IBU concentration was determined spectrophotometrically at 221 nm.
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