PMSS imaging

All PMSS imaging was performed using a dedicated Hewlett Packard 43855B Faxitron apparatus (Faxitron Bioptics LLC, Tucson, AZ, USA), at 3 mAs using a low kilovolt technique. Two images comprising a full-body frontal and lateral view projection (including axial skeleton and extremities) were acquired for all cases. The radiography was always performed prior to the autopsy or any further post-mortem cross-sectional imaging. At Great Ormond Street Hospital, all radiographs are routinely reported by one of seven specialist consultant paediatric radiologists, with >10 years of radiological experience for the assessment of inheritable bone disorders and gestational age estimation.