Randomization

The LPHS patients who meet all criteria after the initial screening period will undergo a renal artery angiogram, at the Interventional Radiology suite, Regina General Hospital, to evaluate renal artery anatomy (arteries with a diameter between 3 and 8 mm are suitable). Only subjects with eligible renal artery anatomy will be randomized to 1 of 2 treatment arms: (1) renal denervation (treatment group), (2) sham treatment (control group) immediately following the renal angiogram. If the renal angiogram shows that renal artery anatomy is not eligible for the study, patients will be excluded from the study. A web-based randomization system (REDCap) will be used by the manager of the Interventional Radiology suite, who is not involved with clinical care, to randomly assign patients to either the treatment or control groups. All patients will have an equal chance to be assigned either treatment group with a 1:1 treatment allocation design being used.