Statistical significance was assessed using a χ2 test for categorical variables and a Student’s t-test or Mann–Whitney test for quantitative variables.
High discordance rate, corresponding to the percentage of significant disagreement, such as negative vs. positive reading or uptake ≥2 grades evaluation between CI and PI interpretation, were calculated.
Concordance analysis between CI and PI interpretation and inter-observer/intra-observer variabilities were assessed by calculating kappa (κ) coefficient (25). According to Landis and Koch scale (26), a κ coefficient of less than 0.2 indicated poor agreement, 0.21–0.4 fair agreement, 0.41–0.6 moderate agreement (MA), 0.61–0.8 good agreement (GA), and 0.81–1 excellent agreement (EA).
All reported p values are two-sided. Significance level was set 0.05. Data were analyzed using SPSS statistical software v20 (IBM).
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