Clear cell-RCC transcriptome data derived from exon array analysis of 20 total samples (10 ccRCC tumor sample and their matched non-tumor kidney tissues samples) were used. Exon array data are deposited in GEO at Series accession number GSE47032. GSEA [64] was used to determine which pathways were statistically enriched across the renal cancer dataset. The normalized enrichment score (NES) was used to evaluate the extent and direction of enrichment of each pathway.
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