4.6. Synthesis of [11C]methyl benzoate

Pd₂[π‐cinnamyl]Cl₂ (2.3 mg; 1eq), xantphos (5.0 mg; 2eq) and iodobenzene (2.2 μL, 2.9 eq) were dissolved in anhydrous THF (700 μL) and the resulting mixture was flushed with N₂ until the THF was fully evaporated (20 min). THF (150 μL) and a solution of lithium methoxide in MeOH (1M, 40 μL) were added and the reaction mixture was introduced into the HPLC loop approximately 2 min prior to start of synthesis. The resulting mixture was allowed to react for 5 min at 120°C.