Statistical analysis

All data are presented as mean ± SE. A 2-tailed paired Student t-test was used to analyze experiments with 2 experimental groups, and a 2-way analysis of variance (ANOVA) with Tukey’s correction for multiple comparisons was used to analyze experiments containing 4 or more groups. Finally, experiments with 3 groups were analyzed using a 1-way ANOVA with Tukey’s correction. If the data were not normally distributed, a log transformation was performed before performing statistical analysis. P < 0.05 was considered significant. GraphPad Prism 8 software was used for all statistical analyses.