Strategy application to the integration of AFGen 2018 GWAS, EWAS, and TWAS.

BW Biqi Wang
KL Kathryn L. Lunetta
JD Josée Dupuis
SL Steven A. Lubitz
LT Ludovic Trinquart
LY Lixia Yao
PE Patrick T. Ellinor
EB Emelia J. Benjamin
HL Honghuang Lin
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We applied our strategy with the optimal weights to integrate 2018 GWAS, EWAS, and TWAS, which would generate a list of candidate genes that might be related to AF. We further examined their functions using the enrichment analysis, tissue-specific expression analysis, and heritability estimations as follows.

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