General procedures for 2-amino-1-phenylethanol (A-series) and 2-amino-2-phenylethanol (B-series) compounds

A-series compounds were prepared by combining different substituted 1-(4-aminophenyl)-2-bromoethanone derivatives with various amines. The carbonyl group in each intermediate was then reduced by sodium borohydride to afford the 2-aminoethanol product (Scheme 1). B-series compounds were synthesized by coupling different substituted 2-bromo-1-phenylethanol compounds with various amines after reduction of the ethanone (Scheme 2). Finally, all of the target compounds were treated with a saturated solution of hydrogen chloride in isopropanol to form hydrochlorides.