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Sedation and a loss of muscle coordination are common CNS-mediated side effects of opioids. To assess the sedative effects of JT09, rats were given JT09 (20 mg/kg, p.o.), saline (0.2 ml, p.o.), or morphine (10 mg/kg, i.p.) 20 min before placement in an automated (68 l × 21 w × 21 h cm) activity chambers for a 30 min test. Morphine was used as a comparison group due to its well-known sedative effects.
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