Patient Population

This retrospective study was approved by the local institutional review board and was compliant with the Health Insurance Portability and Accountability Act. From August 2013 to December 2014, 316 patients underwent multiparametric MR imaging. Among these patients, 74 underwent robot-assisted radical prostatectomy. A total of 299 tissue block sections (four to eight sections per patient) from 48 patients were digitized and included in this study. All patients gave informed consent and had biopsy-proven adenocarcinoma of the prostate. Eight patients had been included in a previous study (19). This study extends the previous study by including 40 more patients and high-b-value DW diffusion weighted imaging and by correlating DHA digital histopathologic analysis and MP multiparametric MR imaging on a region and voxel basis and with respect to Gleason score.