Abbreviations

Lipids were annotated according to the described shorthand notation³² and LIPID MAPS nomenclature³³. Briefly, the different lipid species of PC, phosphatidylethanolamine (PE), phosphatidylserine (PS), phosphatidylinositol (PI), phosphatidic acid (PA), phosphatidylglycerol (PG), and diacylglycerol (DAG) are listed with the two fatty acyl groups separated with a hyphen, e.g., PC 16:0–18:1, when positions are unknown and with a slash, e.g., PC 16:0/16:0, when known. LysoPC and lysoPE are abbreviated as LPC and LPE, respectively, and cholesteryl esters are abbreviated CE. Ether-linked phospholipids are shown as PC O (alkyl), PC P (alkenyl), PE O (alkyl), and PE P (alkenyl). Fatty acyl groups of ether-linked lipids and N-amidated fatty acyl groups for SM, ceramide (Cer), sphingolipids, and gangliosides are shown after the slash. Sphingolipids are: sphingosine (SPH), sphingosine-1-phosphate (S1P), sphinganine-1-phosphate (SA1P), glucosylceramide (GlcCer), lactosylceramide (LacCer), and globotriaosylceramide (Gb3). Gangliosides are: GD1, GM1, GM3, GQ1 and GT2. Fatty acids and eicosanoids are: docosahexaenoic acid (DHA), arachidonic acid (AA), eicosapentaenoic acid (EPA), 12-hydroxyeicosatetraenoic acid (12-HETE), 11-hydroxyeicosatetraenoic acid (11-HETE), 15-hydroxyeicosatetraenoic acid (15-HETE), 8-hydroxyeicosatetraenoic acid (8-HETE), 5-hydroxyeicosatetraenoic acid (5-HETE), prostaglandin E2 (PGE2), prostaglandin D2 (PGD2), 13-hydroxyoctadecadienoic acid (13-HODE), 9- hydroxyoctadecadienoic acid (9-HODE), 6-keto prostaglandin F1α (6-keto-PGF1alpha), prostaglandin F2α (PGF2alpha), tromboxane B2 (TXB2), tromboxane B3 (TXB3), 12-hydroxyeicosapentaenoic acid (12-HEPE), 14,15-dihydroxyeicosatrienoic acid (14_15-DHET), 11,12-dihydroxyeicosatrienoic acid (11_12-DHET), 8,9-dihydroxyeicosatrienoic acid (8_9-DHET), 5,6-dihydroxyeicosatrienoic acid (5_6-DHET), hydroxyoctadecatrienoic acid (13-HOTrE), 12-oxo-eicosatetraenoic acid (12-oxoETE), 5-oxo-eicosatetraenoic acid (5-oxoETE), 5-hydroxyicosapentaenoic acid (5-HEPE), 15-hydroxyicosapentaenoic acid (15-HEPE).

Data resulting from lipidomics analyses have been submitted to MetaboLights [Data Citation 3].