Association Analysis

We further examined whether any observed alterations were related to task performance during scanning as well as clinical symptoms at baseline. For the observed activation differences, we extracted the first eigenvariates from 5-mm spheres around each of the peak coordinates in the group-level contrast map. These eigenvariates were further averaged across all spheres to generate a subject-specific activation metric. Pearson correlations were performed for each group between these subject-specific metrics and performance and symptom variables. Here, task performance was measured using the d’ scores and the mean reaction time during the retrieval session. Clinical symptoms were evaluated by the summed scores of each domain in the SOPS (positive, negative, disorganization, and general).