Virus and virus titration

LCMV strain WE was obtained from Stefan Freigang (Institute of Pathology, University of Bern, Switzerland) and was propagated at a low multiplicity of infection on L929 fibroblast cells. Virus titers were measured using a plaque‐forming assay, as previously described 72. Mice were injected intravenously (i.v.) with 10⁵ plaque‐forming units (pfu) LCMV strain WE, a dose range shown to induce liver immunopathology 20. In the Fig 1C, group size is as follows: for each group of mice, virus titers in the spleen: day 1, n = 9; day 2, n = 9; day 3, n = 3; day 5, n = 3; day 7, n = 3; day 8, n = 9; day 10, n = 11; day 12, n = 6; virus titers in the liver: day 1, n = 3; day 2, n = 3; day 3, n = 3; day 5, n = 3; day 8, n = 6; day 10, n = 8; day 12, n = 3.