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2.9. Rat pharmacology study

MG Marco Gymnopoulos
OB Oscar Betancourt
VB Vincent Blot
RF Ryo Fujita
DG Diana Galvan
VL Vincent Lieuw
SN Sophie Nguyen
JS Jeanette Snedden
CS Christine Stewart
JV Jose Villicana
JW Jon Wojciak
EW Eley Wong
RP Raul Pardo
NP Neki Patel
FD Francois D’Hooge
BV Balakumar Vijayakrishnan
CB Conor Barry
JH John A. Hartley
PH Philip W. Howard
RN Roland Newman
JC Julia Coronella
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Male Sprague Dawley rats were given an intravenous bolus injection of 0.5, 1, 1.5, and 2 mg·kg−1 of ADCs. Body weights and general clinical observations were recorded daily over the entire 21 days of the study. Blood samples for pharmacokinetics (PK) were drawn predose, 4, 24, 48, 96, 168, 336, and 504 h after injection of test articles and collected in heparin‐coated tubes, followed by 14 000 g centrifugation for 5 min. Plasma concentrations of ADCs were measured by ELISA. Noncompartmental pharmacokinetic parameters were calculated using WinNonlin software (Pharsight, Mountain View, CA, USA).

Copyright and License information:  ©2019 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.
This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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