The neural network was constructed and trained using the Keras framework [7] using TensorFlow [8] as backend. The neural network was trained using the back-propagation supervised training algorithm. The loss function of binary cross entropy was minimized using the RMSprop optimizer.
The c-statistics, best accuracy, threshold, sensitivity and specificity of the model and its 95% confidence interval (CI) were calculated using the bootstrap procedure with 2000 bootstrap rounds using the pROC package of R[9].
The statistical analysis of probability of urgent revascularization with each quartile of model output was done using R version 3.5.1. Fisher’s exact test was used to calculate the p value. P value <0.05 were considered as statistically significant.
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