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3.6. Determination of the LogP Values

TR Tiffany K. Rundstadler
AE Arvin Eskandari
SN Sarah M. Norman
KS Kogularamanan Suntharalingam
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The shake-flask method in combination with UV-Vis spectroscopy was used to determine the LogP values of 2–5. Briefly, to a suspension of water (500 μL) and octanol (500 μL), 2–5 was added, giving a final concentration of 100 µM. The mixture was shaken for 24 h (room temperature). Using centrifugation, the water and octanol layers were separated and the concentration of 2–5 in each layer was determined using UV-Vis spectroscopy.

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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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