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Preliminary examination of meropenem was carried out by the means of NMR spectroscopy to provide an indication of how fast meropenem degraded and inform development of the HPLC method. Meropenem solution at the clinically relevant concentration [(1000 mg / 70 mL) × 1000 = 14 285 ppm] was placed in an NMR tube and instrument was programmed to periodically analyze throughout the day. The remainder of reconstituted solution was left at room temperature for 2 weeks and then analyzed by HPLC to understand the characteristics of meropenem degradation product/s.
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