Peptides

MH Miwa Hayashi
KK Kengo Kuroda
KI Kohei Ihara
TI Takahiro Iwaya
EI Emiko Isogai
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The primary amino acid structure of the original LL-37 is LLGD FFR KSK EKI GKE FKR IVQ RIK DFL RNL VPR TES. hCAP is a 27-mer peptide that lacks the first and last 5 amino acids of LL-37. FF/CAP18 (FRK SKE KIG KFF KRI VQR IFD FLR NLV) was designed by replacing a glutamic acid residue and lysine residue with phenylalanine of hCAP18 to enhance its antimicrobial and anticancer properties (11).

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