The triple γ-detection system

ZS Zaitulhusna M. Safee
FB Friedrich Baark
EW Edward C. T. Waters
MV Mattia Veronese
VP Victoria R. Pell
JC James E. Clark
FM Filipa Mota
LL Lefteris Livieratos
TE Thomas R. Eykyn
PB Philip J. Blower
RS Richard Southworth
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We have described the design of our triple γ-detection system, and its use for pharmacokinetic characterization of radiotracers in the Langendorff perfused heart previously23,24. Briefly, it comprises three orthogonal lead-collimated Na/I γ-detectors arrayed around a perfusion apparatus, positioned (i) 3 cm downstream of a radiotracer injection port on the arterial line, 15 cm upstream of the heart cannula (to provide a radiotracer input function), (ii) directly opposite the heart (to monitor cardiac retention), and (iii) over the venous outflow line (to provide an output function). Each detector was connected to a modified GinaSTAR™ ITLC system running Gina™ software for real-time data collection (Raytest Ltd, UK).

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