We will evaluate the quality of the included economic evaluations by use of the 10-item Drummond checklist [19] and the CHEERS statement [20]. We will also evaluate whether the economic evaluations adequately considered context-specific issues, which may influence the ability of an evaluation to address the decision problem. For example, this may include how the evaluations accounted for changes to treatment regimens or patient weight gain during the analysis horizon. Each study will be appraised independently by two reviewers, with conflicts resolved by discussion.
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