ASO preparation and treatment.

C1INH ASO (murine sequence) (Bhattacharjee et al., 2013) and control ASO (CTRL ASO, no homologies to the mouse genome) were provided by Ionis Pharmaceuticals. C1INH ASO and CTRL ASO were dissolved in saline and injected subcutaneously to ten-week-old mice at 150 mg/kg/week for the first two weeks (3 times a week at 50 mg/kg for two weeks) and then reduced to 50 mg/kg/week for 10 weeks (twice a week at 25 mg/kg for 10 weeks) (n=6–14 mice/group per cohort).