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All potential participants completed a 2 week, single-blind, placebo run-in period with subsequent randomisation of eligible participants done centrally using an interactive web response system and a computer-generated randomisation schedule. Participants in CANVAS were randomly assigned in a 1:1:1 ratio to receive canagliflozin 300 mg, canagliflozin 100 mg or matching placebo, and participants in CANVAS-R were randomly assigned in a 1:1 ratio to receive canagliflozin or matching placebo (initially 100 mg with optional uptitration to 300 mg).
Copyright and License information: The Author(s) ©2019
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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