2.5. Trial intervention

Eligible patients will be randomized to receive FCM or placebo.

FCM solution (Ferinject) will be given as an IV perfusion of 20 mL (equivalent to 1000 mg of iron) diluted in a sterile saline solution (0.9% NaCl) and administered over ≥15 minutes.

Because FCM is a dark‐brown solution and easily distinguishable, the personnel responsible for its preparation and administration will not be involved in any study assessments. To ensure that patients will be unaware of the study drug, the materials used in drug administration will be covered with aluminum foil or other opaque material and the injection site will be shielded from patient view.

Normal saline (0.9% NaCl) will be administered as per the instructions in the placebo group.

The indication for other HF drugs will be followed according to the current recommendations for clinical practice.