Intensive versus standard glycemic control

Because RECODe excludes a variable for intensive versus standard glycemic control, the probabilities obtained from RECODe best represent an average risk for a given trial patient. However, diabetes outcomes may differ depending on the intensity of glycemic control, particularly for microvascular outcomes.⁵³ In PREDICT-DM, we adjust the transition probabilities of MI, death from an MI event, stroke, death from a stroke event, other cardiovascular deaths, microalbuminuria, and macroalbuminuria for patients receiving intensive versus standard glucose control using literature-derived risk ratios.^54–57 Supplementary Table S4 in Supplementary Appendix F provides the multipliers used within PREDICT-DM to adjust risk of events for intensive versus standard glycemic control.