The principle of a pseudonymized (each patient was encoded by sex, age and the first three digits of the postal code) documentation was approved by the local ethics committee of the medical department of Goethe University in Frankfurt on October 30, 2017 (Ethik-Kommission des Fachbereichs Medizin der Goethe Universität Frankfurt, 30.10.2017, 332/17).
The study has been registered under DRKS00012708 (http://www.drks.de).
All the principles outlined in the Declaration of Helsinki of 1975 have been followed in this retrospective study.
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