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Synthesis of methyl 3,4,5-trimethoxycinnamate

OO Olumayokun A. Olajide
IA Idowu S. Akande
CF Carlos da Silva Maia Bezerra Filho
IL Izabela Lepiarz-Raba
DS Damião Pergentino de Sousa
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MTC was synthesised as earlier described (da Nóbrega et al. 2018). To a solution of 3,4,5-trimethoxycinnamic acid (0.25 g) in 250 mL of MeOH, 0.5 mL 96% (v/v) H2SO4 was added under stirring. The reaction mixture was refluxed for 3 h. Half of MeOH was removed under reduced pressure and the following solution was then diluted with 10-mL water and the product extracted with ethyl acetate. The organic phase of the reaction was successively washed with 5% (w/v) NaHCO3 (twice) and water, dried over anhydrous Na2SO4 and filtered. After removal of ethyl acetate under vacuum, the methyl 3,4,5-trimethoxycinnamate was obtained.

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