The primary outcome was symptomatic VTE caused by lower extremity DVT or pulmonary embolism (PE), determined by CT pulmonary angiography (CTPA) or compression ultrasonography (CUS). In intubated patients, symptomatic VTE was defined as imaging performed because of clinical findings suggestive of VTE. No surveillance imaging was performed. Suspected PE events in mechanically ventilated unstable patients with respiratory decompensation, right heart strain on echocardiogram, and a decision to move to therapeutic anticoagulation for suspected PE, were reviewed and confirmed by three authors. Major bleeding was defined using International Society on Thrombosis and Haemostasis4 criteria. ARDS was defined by Berlin criteria.5
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