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PRMT5 inhibitor C220 was synthesized by WuXi Apptech. It was administered in a vehicle consisting of 0.5% methylcellulose, 0.1% Tween-80, and 99.4% sterile water. Mice were given C220 (2 mg/kg) by oral gavage once a week starting day +7 after transplant till the end of the study. For the NSG experiment alone, mice were dosed 3 times weekly. Mice in the control group were treated with the same volume of vehicle as the C220 group.
Copyright and License information: ©2020 American Society for Clinical Investigation
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