2.2. Inclusion criteria

Patients of coronavirus disease 2019 with positive nucleic acid test will be included, regardless of gender and race.

The intervention of the experimental group contains acupuncture, which included warm acupuncture, electroacupuncture, scalp-acupuncture, hydroacupuncture, and manual acupuncture. The control group could use any kinds of treatments, which may be western medicine, Chinese herbal medicine, placebo, or regular treatment, except acupuncture.

Hamilton Anxiety Scale (HAM-A)^[11] was created in 1959 and has been used for measuring the severity of perceived anxiety symptoms till today, is also considered one of the most widely used rating scales.

The Liebowitz Social Anxiety Scale (LSAS),^[12] which is the most frequently used for assessing social anxiety disorder (SAD) in clinical research and practice; (modified) Barthel index (MBI),^[13] is usually used for measuring individual's performance on activities of daily living (ADL) functions.

Side effect or adverse event of included studies will be utilized for safety analysis.

We will include randomized controlled trials (RCTs).