2.1. Selection of Patients

This was a multicenter retrospective observational study from a routine clinical practice in the University Hospital in Hradec Kralove, Masaryk University Hospital in Brno, University Hospital in Ostrava, and University Hospital in Kralovske Vinohrady, Prague, which took place in the period from July 2017 to August 2019. The criteria for inclusion were as follows:

Pathologic myopia with an axial length of 26 mm or more, presence of active subfoveal or juxtafoveal CNV, which was demonstrated by means of fluorescent angiography (FA), and a one-year follow-up period (Figure 1). The criteria for exclusion were as follows: CNV resulting from causes other than myopia (e.g., age-related macular degeneration (AMD), central serous chorioretinopathy, diabetic retinopathy, retinal vein occlusion, vasculitis, and uveitis), previous treatment of CNV (including photodynamic therapy (PDT) and intravitreal injections of anti-VEFG drugs), and other possible causes of decreased BCVA (e.g., advanced cataract and other disease of the retina and/or the anterior segment). All included patients were treatment naïve, and no one patient was bilaterally affected. The baseline BCVA ranged between 75 and 25 letters of the ETDRS optotypes (Snellen 20/32–20/320) on the affected eye.

Choroidal neovascularization in a patient with pathological myopia. (a) Fundus photography before Lucentis treatment. Acute neovascular membrane and subretinal hemorrhage in the nasal part. (b-c) HD-OCT before treatment. Hyperreflective tissue grows through retinal pigment epithelium. Central retinal thickness is 675 μm. (d-e) HD-OCT after treatment. A decrease of edema and improvement of foveolar depression. (f) Fundus photography after treatment. Reduction of neovascular membrane, and hemorrhages are not presented.