Subjects

Tissue from the primary motor cortex area located in the precentral gyrus (Brodmann’s area 4) [Fr (BA4)] and the spinal cord (cervical and lumbar areas) were obtained from ALS subjects (Tables 1 and ​and2).2). Age-matched samples obtained from subjects that had no clinical history of any neurological disorders were used as controls (Tables 1 and ​and2).2). These specimens were obtained from the Cognitive Neurology and Alzheimer’s Disease Center Brain Bank at Northwestern University and the New York Brain Bank at Columbia University. The specimens were used for quantitative western blot analysis as described below.

Frontal cortex tissue analyzed in this study.

Fr (BA4): frontal cortex Brodmann area 4; Unk: unknown.

Spinal cord tissue analyzed in this study.

SCL: spinal cord lumbar area; SCC: spinal cord cervical area; Unk: unknown.