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We used genotyping array data from UK Biobank participants to calculate a previously described weighted LPA genetic risk score (GRS), composed of 43 single-nucleotide variants that were conditionally and significantly associated with lipoprotein(a) levels in data sets external to the UK Biobank (eTable 1 and eMethods in the Supplement). The units of the LPA GRS were converted from milligrams per deciliter to nanomoles per liter by multiplying by 2.15 to harmonize units with the measured lipoprotein(a). An LPA GRS of at least 120 was considered elevated.
Copyright and License information: ©2020 Trinder M et al. .
This is an open access article distributed under the terms of the CC-BY License.
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